Save your own brain then
This movie is the best in the world - if you want a real bad movie. If you want a good B-Movie - its ....
First third or so filmed nearly a century after the main "story" (not that it has a real story) - the main actors of this part stumble around without much of a connection to the earlier (here later) part, and are all killed. That is, of course, they couldn't join in with the other actors ten years back in time.
The rest of the movie isn't much better - forget about the storyline. You sit around the whole time thinking: "When does the story start - wheres the action, the thrill, the humor, the sense?"
Even my hopes for an evil, entriguing or even power-mad super-villianous Hitler were eradicated. This guy (who by the way dont looks a bit like the old "Gröfaz") just stares out of his jar and, I suppose, wonders, why not one of his plain stupid Nazi henchmen speaks one word German.
The rest is 50s B-Movie standart: Screaming girl, smart hero, dead villains, etc.. The damn brain - which is the whole head in truth - not even gets a cool showdown or death scene. It simply burns to death in its car - still staring around helpless.
The most frightening on this movie is the hair-style of the main charakter in the first part.
Only good thing about this movie is the fact, that people are surprised (or shocked) when they see it in your movie collection. Nobody believes, that somebody ever did a "They saved Hitlers Brain" movie.
Here in Germany, where I live, its double shock.

Hummm
Saw this one at the Drive in, a long long time ago and now that
i purchased and viewed, its as strange a i remember it.
The first 1/3rd of the film runs like a home made movie that they
appended to the film..once gone the film is more interesting.
Nothing like seeing Hitler's head on that box with lots of dials
on it. One movie that should make your bad movie collection

My all-time favorite bad movie
I first saw this in the wee hours of the morning, several years before the proliferation of the video tape recorder. I remembered it and watched it again when it turned up a year or two later. I've always thought that watching bad movies in the wee hours when you're half asleep is the only way to go. Watching them on video destroys the ambience! The movie is indeed a pastiche of two separate films with separate casts, shot years apart. However, I take issue with Leonard Maltin and the others who refer to the Stanley Cortez footage as being from the 1950s. The actors are dancing The Twist in the Dos Palabras club in one scene. The Twist became a craze in the Fall of 1960, and remained all the rage for the next couple of years. The original Madmen of Mandoras was released in 1963 (I have a 22X28 poster, complete set of lobby cards, and some stills from this flick); all this is consistent with an early '60s filming of the Cortez footage. The added footage was probably filmed in the late 60s. I have the autographs of a number of the cast members of this masterpiece. Nestor Paivia, who plays the police chief, is perhaps best remembered as the skipper of the skiff in Creature from the Black Lagoon. Joe Bob sez check it out.